International Mobility – Reflections by Sonia KHIER, Associate Professor
My Background
I studied pharmacy, with a fifth year focused on research and a sixth year in a pharmacy. I passed the residency exam at the end of my sixth year.
I completed my four-year residency in Montpellier/Nîmes, specializing first in hospital pharmacy and then in industrial pharmacy and medical biology. During my residency, I specialized in pharmacokinetic modeling, notably through an internship at Sanofi, and, alongside my residency, I pursued a university thesis. It was at the end of my studies that I took the competitive exam for a faculty-researcher position because a position was open in pharmacokinetics, though initially I was leaning more toward a career in industry.
My teaching activities
I primarily teach pharmacokinetics: mechanistic pharmacokinetics, pharmacokinetic modeling, and AI methods used in the development of pharmacokinetic models. I currently teach mainly in the Master’s program in Epidemiology, Health Data, and Biostatistics (EDSB) and in the Industry track, after having been heavily involved in and taught in the Internship track in the past.
My research activities
The focus of my research is the development of pharmacokinetic models that establish a relationship between dose, exposure, and patients’ clinical response to treatment. These models also help identify factors contributing to interpatient variability. They support the personalized use of certain therapeutic classes (antibiotics, immunosuppressants, anticancer drugs, etc.) by proposing individualized dosing regimens for each patient. In other situations, they provide the only dosage recommendation available. This is particularly the case for patient populations for whom no dosage is recommended by the marketing authorization (pediatric patients, patients with rare diseases, women, or pregnant women).
My international mobility in 2022–2023
Research leave (CRCT) allows faculty members to devote themselves entirely to their research for a specified period. In my case, I was granted a one-year CRCT through the National Council of Universities (CNU).
I structured this research project over two semesters; my goal was to focus on using innovative pharmacokinetic modeling methods so that I could develop models tailored to pediatric patients and pregnant women.
I spent six months at Geneva University Hospital working with Professor Ansari’s pediatric oncology department to develop a model aimed at reducing infant mortality (children aged 0 to 2 years) associated with the use of busulfan. Indeed, for this population of children, it is particularly difficult to find effective, non-toxic dosages due to physiological (and thus pharmacokinetic) and pathological heterogeneity. The model developed partially addresses this challenge.
Next, I spent six months working with Dr. Niina Kleiber, a pediatrician at Sainte Justine Hospital in Montreal, who is a leading expert in the treatment of vascular anomalies (an orphan disease encompassing a range of symptoms). Of the 87 medications used to treat these children, only two have marketing authorization for pediatric use. I am developing pharmacokinetic models for several of these drugs in order to propose appropriate dosages for these patients.
During my exchange, I also established a partnership with the Medicines for Malaria Venture (MMV) with the goal of improving our understanding of pharmacokinetics in pregnant women so that they can safely use the medications they need, since even here, marketing authorizations that specify dosages appropriate for pregnant women are few and far between, even though they require tailored care.
Together with MMV and other foundations, we have also developed a training network across Africa to make training in pharmacokinetic modeling (or pharmacometrics) more accessible, and we regularly provide training to students and healthcare professionals on the continent. The most recent training sessions took place in Uganda and Senegal.