"Pharmacy Tuesdays" Lecture – April 4

Abstract: Due to their numerous unsaturated bonds, polyunsaturated fatty acids (PUFAs) are prone to oxidation (peroxidation). Lipid peroxidation is a common phenomenon in PUFAs, which is itself often caused by oxidative stress. This peroxidation then leads to the metabolism of the fatty acid and the formation of metabolites called oxylipins. These oxylipins may have therapeutic activities or be used as biomarkers of oxidative stress. There are numerous oxylipin structures, and the individual study of each structure requires the use of chemical synthesis. During this presentation, I will discuss work on multi-step total synthesis aimed at obtaining these oxylipins, followed by their applications as biomarkers or potential drugs.