"Pharmacy Tuesdays" conference – April 4

Abstract: Due to their numerous unsaturations, polyunsaturated fatty acids (PUFAs) are prone to oxidation (peroxidation). Lipid peroxidation is a common phenomenon in PUFAs, which is often caused by oxidative stress. This peroxidation leads to the metabolization of fatty acids and the formation of metabolites called oxylipins. These oxylipins may have therapeutic activities or be used as biomarkers of oxidative stress. There are many different oxylipin structures, and studying each one individually requires chemical synthesis. In this presentation, I will discuss work on multi-step total synthesis aimed at obtaining these oxylipins, followed by their applications as biomarkers or potential drugs.