Pharmacy Tuesdays" conference - April 04

Summary: Due to their numerous unsaturations, polyunsaturated fatty acids (PUFAs) are prone to oxidation (peroxidation). Lipid peroxidation is a classic phenomenon among PUFAs, and is itself often due to oxidative stress. This peroxidation then leads to fatty acid metabolism, and the formation of metabolites known as oxylipins. These oxylipins can have therapeutic activities, or be used as biomarkers of oxidative stress. There are many different structures of oxylipins, and the individual study of each structure requires chemical synthesis. In this talk, I will present work on multi-step total synthesis to obtain these oxylipins, followed by applications as biomarkers or potential drugs.