Topical lipid formulations: the benefits of polyoxazolines for targeted delivery

Lecture by Laurianne SIMON from the Pharmacie Galénique Biomatériaux et Cosmétologie laboratory and the ICGM as part of the Mardis de Pharmacie program.

The skin, the main protective barrier against external aggression, is increasingly under attack from environmental sources. Daily aggressions (pollution, tobacco, UV rays...) generate an overproduction of free radicals, leading to premature aging of the skin and promoting the development of skin pathologies and cancers. To effectively neutralize excess radicals, we need to deliver active ingredients (antioxidants) in situ, deep into the epidermis. But how can we effectively penetrate the skin without damaging it?

To achieve this goal, we at the ICGM, in Prof. Sylvie Begu's team, have developed tailor-made lipid nanoformulations to deliver antioxidants to the epidermis. These nanoformulations were developed using polyoxazolines, bio-inspired polymers that partly mimic the structure of our skin. This enabled us to assess the physico-chemical properties of the polymeric formulations and validate their efficacy in vitro and in vivo. The formulations were able to penetrate the skin without damaging the cells, delivering antioxidants encapsulated in the epidermis.

This work paves the way for new skin therapies to treat pathologies such as psoriasis and melanoma, which are becoming increasingly prevalent worldwide.

Face-to-face in AMPHI J or by video: